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KMID : 0606320010170010041
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Journal of Phamacetical Sciences Sookmyung Women s University
2001 Volume.17 No. 1 p.41 ~ p.45
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Inhibitory Effect of Cactus on Adjuvant-Induced Angiogenesis in Mice
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Park Eun-Hee
Kahng Ja-Hoon
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Abstract
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Cactus (Opuntia ficus-indica var. saboten Makino) has been widely used as a folk medicine. It was previously found that the alcoholic extract of cactus showed anti-inflammatory activity. In the present study, anti-angiogenic effects of the methanolic extract and its subtractions was investigated using adjuvant-induced pouch granuloma model in mice. The methanolic extract showed a significant anti-angiogenic effect. Among subtractions, the hexane subtraction was the most effective in anti-angiogenic activity. These results suggest that cactus contains potent anti-angiogenic principles in addition to its anti-inflammatory effect.
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